Histone H2B anticorps (Biotin)

N° du produit ABIN6983098

Cet anticorps Souris Monoclonal détecte spécifiquement Histone H2B dans IHC (p). Il présente une réactivité envers Humain, Souris et Rat.

Aperçu rapide pour Histone H2B anticorps (Biotin) (ABIN6983098)

Antigène: Histone H2B

Reactivité: Humain, Souris, Rat

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Histone H2B est conjugé à/à la Biotin

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: 4H9

Détail du produit anti-Histone H2B anticorps (Biotin)

Réactivité croisée: Humain, Souris, Rat

Purification: Purified by Protein G.

Immunogène: KLH conjugated synthetic peptide derived from human Histone H2B

Isotype: IgG

Information d'application

Indications d'application: IHC-P 1:200-400

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C for 12 months.

Date de péremption: 12 months

Détails sur Histone H2B

Antigène: Histone H2B

Sujet:

Synonyms: H2B.1 A, H2B/a, H2B/g, H2B/h, H2B/k, H2B/l, H2B/l.

Background: In diploid eukaryotic cells, the chromatin fibers are about 20nM in diameter. They consist of two major components in equal amounts, DNA and basic proteins called histones. Histones are believed to be regularly arranged in the deep groove of the DNA helix. The recurring positive charges of the histones form electrostatic associations with the negatively charged phosphate groups of DNA, making the DNA more stable and flexible. This allows for the supercoiling of the chromatin fibers. Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. Linker histones are involved in the formation of higher order structure in chromatin and the maintenance of overall chromatin compaction. Whilst the core histones are highly conserved across a wide range of organisms, the linker histones are less conserved.

ID gène: 3018

UniProt: P33778